Anti-human RP105 sera induces lymphocyte proliferation

Antigens of human trophoblast. Effects of heterologous anti-trophoblast sera on lymphocyte responses in vitro

This report describes the inhibition of human mixed lymphocyte culture (MLC) reactions by rabbit antisera to intact and detergent solubilized, fractionated, human trophoblast membranes. Heat-inactivated antisera were passed through solid-phase immunoabsorption columns of normal human serum and extensively absorbed with human erythrocytes, lymphocytes and liver powder. Immunohistological experim...

CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes.

Lipopolysaccharide (LPS) is a major gram-negative bacterial component that stimulates innate immune response and also induces B-lymphocyte activation. Recent studies have revealed that common molecular patterns of microorganisms such as LPS are recognized by toll-like receptors (TLRs). B cells have 2 known TLRs that mediate LPS signaling, TLR4 and RP105 (CD180). While TLR4 is expressed on immun...

Anti-Human CD4 Induces Peripheral

Reversal of immunosuppression of lymphocyte proliferation caused by sera from persons with AIDS.

Sera from persons with AIDS contain inhibitors of lymphocyte proliferation. Inhibitory activity can be detected before the development of AIDS in humans. There appear to be at least three distinct suppressive moieties, one of which is prostaglandin E2. We and others had previously shown that serum samples from subjects with AIDS contained antibody to the cell line HUT 102B2. We attempted to rem...

Anti- Idiotype Sera Raised

Present concepts of the maturation of a B-lymphocytic clone involve progressive changes in cellular morphology and mode of immunoglobulin (Ig) production. The ancestral small lymphocyte synthesizes Ig for insertion into its plasma membrane, while those of its descendants destined to produce humoral antibody show first a superimposed synthesis of Ig for export and finally a heavy export with lit...